scikit-chem is a high level cheminformatics library built on rdkit that aims to integrate with the Scientific Python Stack by promoting interoperativity with libraries such as pandas and scikit-learn, and emulating similar patterns and APIs as found in those libraries.
Some notable features include:
Pythonic core API
A simple interface for chemical datasets
Structure visualization
Interactivity in Jupyter Notebooks
scikit-chem should be thought of as a simple complement to the excellent rdkit - scikit-chem objects are subclasses of rdkit objects, and as such, the two libraries can usually be used together easily when the advanced functionality of rdkit is required.